KBTBD7:CUL3:RBX1 ubiquitinates NF1 [GO_0061630]
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. This enzyme catalyzes a transferase reaction.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen KBTBD7:CUL3:RBX1 ubiquitinates NF1 in VFB
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0061630",
"symbol": "",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0061630",
"label": "KBTBD7:CUL3:RBX1 ubiquitinates NF1"
},
"description": [
"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues."
],
"comment": [
"This enzyme catalyzes a transferase reaction."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0061659",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0061659",
"label": "ubiquitin-like protein ligase activity"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0004842",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0004842",
"label": "SYVN1 ubiquitinates Hh C-terminal fragments"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "ubiquitin protein ligase activity involved in ERAD pathway",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
},
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "ubiquitin protein ligase activity involved in chloroplast disassembly",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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