I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus [GO_0008440]

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            "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+."
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