phospholipid scramblase activity [GO_0017128]
Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases).
Note
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VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0017128",
"symbol": "",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0017128",
"label": "phospholipid scramblase activity"
},
"description": [
"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism."
],
"comment": [
"Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases)."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0005548",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0005548",
"label": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0140303",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0140303",
"label": "intramembrane lipid transporter activity"
}
],
"relationships": [
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/BFO_0000050",
"label": "is part of",
"type": "part_of"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0017121",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0017121",
"label": "plasma membrane phospholipid scrambling"
}
}
],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [],
"def_pubs": [
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
]
}
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