Defective PAH does not hydroxylate L-Phe to L-Tyr [GO_0004505]

Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.

Open Defective PAH does not hydroxylate L-Phe to L-Tyr in VFB

Term Information

  • ID: GO_0004505
  • Name: Defective PAH does not hydroxylate L-Phe to L-Tyr
  • Definition: Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.
  • Synonyms:
  • Type:
  • Comment:

VFB Term Json

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    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0004505",
            "symbol": "",
            "types": [
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                "Class"
            ],
            "short_form": "GO_0004505",
            "unique_facets": [
                "Class"
            ],
            "label": "Defective PAH does not hydroxylate L-Phe to L-Tyr"
        },
        "description": [
            "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin."
        ],
        "comment": []
    },
    "query": "Get JSON for Class",
    "version": "275438e",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0016714",
            "types": [
                "Entity",
                "Class",
                "has_subClass"
            ],
            "short_form": "GO_0016714",
            "unique_facets": [
                "Class"
            ],
            "label": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/GO_0019293",
                "types": [
                    "Entity",
                    "Class"
                ],
                "short_form": "GO_0019293",
                "unique_facets": [
                    "Class"
                ],
                "label": "tyrosine biosynthetic process, by oxidation of phenylalanine"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_exact_synonym",
                "label": "phenylalanine hydroxylase activity",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
                        "Entity",
                        "Individual",
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                    ],
                    "short_form": "Unattributed",
                    "unique_facets": [
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                    ],
                    "label": ""
                },
                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
            }
        },
        {
            "synonym": {
                "scope": "has_related_synonym",
                "label": "PAH activity",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
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                },
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                "DOI": ""
            }
        }
    ],
    "def_pubs": []
}