DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A [GO_0034038]
Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+. Note that this term is equivalent to the obsolete molecular function term ‘deoxyhypusine synthase activity ; GO:0004171’ and corresponds closely to the biological process term ‘deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983’.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A in VFB
Term Information
- ID: GO_0034038
- Name: DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A
- Definition: Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+.
- Synonyms:
- Type:
- Comment: Note that this term is equivalent to the obsolete molecular function term ‘deoxyhypusine synthase activity ; GO:0004171’ and corresponds closely to the biological process term ‘deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983’.
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0034038",
"symbol": "",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0034038",
"unique_facets": [
"Class"
],
"label": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A"
},
"description": [
"Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+."
],
"comment": [
"Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'."
]
},
"query": "Get JSON for Class",
"version": "275438e",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0016765",
"types": [
"Entity",
"Class",
"has_subClass"
],
"short_form": "GO_0016765",
"unique_facets": [
"Class"
],
"label": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_related_synonym",
"label": "eIF-5A-deoxyhypusine synthase activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"short_form": "Unattributed",
"unique_facets": [
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],
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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