first spliceosomal transesterification activity [GO_0000384]

Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5’ splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3’ exon.
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Open first spliceosomal transesterification activity in VFB

Term Information

  • ID: GO_0000384
  • Name: first spliceosomal transesterification activity
  • Definition: Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5’ splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3’ exon.
  • Synonyms:
  • Type:
  • Comment:

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0000384",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0000384",
            "unique_facets": [
                "Class"
            ],
            "label": "first spliceosomal transesterification activity"
        },
        "description": [
            "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon."
        ],
        "comment": []
    },
    "query": "Get JSON for Class",
    "version": "3b19da3",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0140098",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0140098",
            "unique_facets": [
                "Class"
            ],
            "label": "catalytic activity, acting on RNA"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/GO_0000375",
                "types": [
                    "Entity",
                    "Class"
                ],
                "short_form": "GO_0000375",
                "unique_facets": [
                    "Class"
                ],
                "label": "RNA splicing, via transesterification reactions"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_related_synonym",
                "label": "lariat formation, 5'-splice site cleavage",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
                        "Entity",
                        "Individual",
                        "pub"
                    ],
                    "short_form": "Unattributed",
                    "unique_facets": [
                        "pub"
                    ],
                    "label": ""
                },
                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
            }
        }
    ],
    "def_pubs": []
}