GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [GO_0004377]
Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity in VFB
Term Information
- ID: GO_0004377
- Name: GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
- Definition: Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
- Synonyms:
- Type:
- Comment:
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0004377",
"symbol": "",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0004377",
"unique_facets": [
"Class"
],
"label": "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"
},
"description": [
"Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage."
],
"comment": []
},
"query": "Get JSON for Class",
"version": "3b19da3",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0000026",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0000026",
"unique_facets": [
"Class"
],
"label": "Defective ALG9 does not add the last mannose to the N-glycan precursor"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0004376",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0004376",
"unique_facets": [
"Class"
],
"label": "glycolipid mannosyltransferase activity"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_related_synonym",
"label": "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "Unattributed",
"unique_facets": [
"pub"
],
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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