N-terminal protein N-methyltransferase activity [GO_0071885]

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
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Open N-terminal protein N-methyltransferase activity in VFB

Term Information

  • ID: GO_0071885
  • Name: N-terminal protein N-methyltransferase activity
  • Definition: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
  • Synonyms:
  • Type:
  • Comment:

VFB Term Json

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            "iri": "http://purl.obolibrary.org/obo/GO_0071885",
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            "short_form": "GO_0071885",
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            "label": "N-terminal protein N-methyltransferase activity"
        },
        "description": [
            "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser."
        ],
        "comment": []
    },
    "query": "Get JSON for Class",
    "version": "275438e",
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            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0008757",
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            "short_form": "GO_0008757",
            "unique_facets": [
                "Class"
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            "label": "S-adenosylmethionine-dependent methyltransferase activity"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0008276",
            "types": [
                "Entity",
                "Class",
                "has_subClass"
            ],
            "short_form": "GO_0008276",
            "unique_facets": [
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            ],
            "label": "PRMT1 methylates ESRs"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_narrow_synonym",
                "label": "X-Pro-Lys N-terminal methyltransferase",
                "type": ""
            },
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                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
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    "def_pubs": []
}