nuclear receptor activity [GO_0004879]
A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to ‘GO:0030374 ; nuclear receptor transcription coactivator activity’ or GO:0140536 ; nuclear corepressor activity.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen nuclear receptor activity in VFB
VFB Term Json
{
"term": {
"core": {
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"symbol": "",
"types": [
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"short_form": "GO_0004879",
"label": "nuclear receptor activity"
},
"description": [
"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus."
],
"comment": [
"Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
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{
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"short_form": "GO_0038023",
"label": "signaling receptor activity"
},
{
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"types": [
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"short_form": "GO_0098531",
"label": "ligand-activated transcription factor activity"
},
{
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{
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"label": "vitamin D receptor activity",
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},
{
"synonym": {
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"label": ""
},
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},
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "nuclear hormone receptor",
"type": ""
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"label": ""
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}
},
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "RXR",
"type": ""
},
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},
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"synonym": {
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"label": "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding",
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},
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "calcitriol receptor activity",
"type": ""
},
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},
{
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"label": "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding",
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},
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},
{
"synonym": {
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"label": "vitamin A receptor activity",
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},
{
"synonym": {
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"label": "retinoic acid receptor activity",
"type": ""
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"label": ""
},
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"DOI": ""
}
},
{
"synonym": {
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"label": "9-cis retinoic acid receptor activity",
"type": ""
},
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"label": ""
},
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"DOI": ""
}
},
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "thyroid hormone receptor activity",
"type": ""
},
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},
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},
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "juvenile hormone receptor activity",
"type": ""
},
"pub": {
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"short_form": "Unattributed",
"label": ""
},
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"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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