oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO_0000703]
Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1’ glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3’ of the apyrimidinic (AP) site. Consider also annotating to the molecular function term ‘DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906’.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity in VFB
Term Information
- ID: GO_0000703
- Name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
- Definition: Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1’ glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3’ of the apyrimidinic (AP) site.
- Synonyms:
- Type:
- Comment: Consider also annotating to the molecular function term ‘DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906’.
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0000703",
"symbol": "",
"types": [
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],
"short_form": "GO_0000703",
"unique_facets": [
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],
"label": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"
},
"description": [
"Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."
],
"comment": [
"Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'."
]
},
"query": "Get JSON for Class",
"version": "275438e",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0000702",
"types": [
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"short_form": "GO_0000702",
"unique_facets": [
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"label": "oxidized base lesion DNA N-glycosylase activity"
}
],
"relationships": [],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
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"label": "endodeoxyribonuclease III",
"type": ""
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},
{
"synonym": {
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"label": "endonuclease VIII activity",
"type": ""
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},
{
"synonym": {
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"label": "DNA glycosylase/AP-lyase",
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},
{
"synonym": {
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"label": "DNA glycosylase/beta-lyase",
"type": ""
},
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"label": ""
},
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},
{
"synonym": {
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"label": "bifunctional DNA glycosylase",
"type": ""
},
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"label": ""
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},
{
"synonym": {
"scope": "has_related_synonym",
"label": "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
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"label": ""
},
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}
},
{
"synonym": {
"scope": "has_related_synonym",
"label": "endonuclease III",
"type": ""
},
"pub": {
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"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"label": ""
},
"FlyBase": "",
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}
}
],
"def_pubs": []
}
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