phospholipid scramblase activity [GO_0017128]

Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases).

Open phospholipid scramblase activity in VFB

VFB Term Json

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    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0017128",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0017128",
            "label": "phospholipid scramblase activity"
        },
        "description": [
            "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism."
        ],
        "comment": [
            "Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases)."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0005548",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0005548",
            "label": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0140303",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0140303",
            "label": "intramembrane lipid transporter activity"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
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                "iri": "http://purl.obolibrary.org/obo/GO_0017121",
                "types": [
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                    "Class"
                ],
                "short_form": "GO_0017121",
                "label": "plasma membrane phospholipid scrambling"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [],
    "def_pubs": [
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}