Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol [GO_0004839]

Catalysis of the reaction: E1 + ubiquitin + ATP–> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. The ubiquitin activating enzyme catalyzes a ligation reaction.
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Open Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol in VFB

VFB Term Json

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    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0004839",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0004839",
            "label": "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol"
        },
        "description": [
            "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate."
        ],
        "comment": [
            "The ubiquitin activating enzyme catalyzes a ligation reaction."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0008641",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0008641",
            "label": "ubiquitin-like modifier activating enzyme activity"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/GO_0016567",
                "types": [
                    "Entity",
                    "Class"
                ],
                "short_form": "GO_0016567",
                "label": "protein ubiquitination"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_related_synonym",
                "label": "E1 ubiquitin-activating enzyme",
                "type": ""
            },
            "pub": {
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                    "iri": "http://flybase.org/reports/Unattributed",
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                    "short_form": "Unattributed",
                    "label": ""
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                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
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        }
    ],
    "def_pubs": []
}