PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [GO_0016308]

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            "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+."
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