PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter [GO_0046976]

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein.
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Open PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter in VFB

VFB Term Json

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        },
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            "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein."
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        "comment": []
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            "short_form": "GO_0018024",
            "label": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)"
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