RNA splicing, via transesterification reactions [GO_0000375]

Splicing of RNA via a series of two transesterification reactions. Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.
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Open RNA splicing, via transesterification reactions in VFB

Term Information

  • ID: GO_0000375
  • Name: RNA splicing, via transesterification reactions
  • Definition: Splicing of RNA via a series of two transesterification reactions.
  • Synonyms:
  • Type:
  • Comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.

VFB Term Json

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            "iri": "http://purl.obolibrary.org/obo/GO_0000375",
            "symbol": "",
            "types": [
                "Entity",
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            "short_form": "GO_0000375",
            "unique_facets": [
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            ],
            "label": "RNA splicing, via transesterification reactions"
        },
        "description": [
            "Splicing of RNA via a series of two transesterification reactions."
        ],
        "comment": [
            "Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism."
        ]
    },
    "query": "Get JSON for Class",
    "version": "3b19da3",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0008380",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0008380",
            "unique_facets": [
                "Class"
            ],
            "label": "RNA splicing"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_related_synonym",
                "label": "spliceosomal catalysis",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
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                        "Individual",
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                    ],
                    "short_form": "Unattributed",
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                },
                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
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    "def_pubs": []
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