SPPL2a/b cleaves TNF(1-76) [GO_0042500]

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
Tags:

Open SPPL2a/b cleaves TNF(1-76) in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/GO_0042500",
            "symbol": "",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0042500",
            "label": "SPPL2a/b cleaves TNF(1-76)"
        },
        "description": [
            "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane."
        ],
        "comment": [
            "Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/GO_0004190",
            "types": [
                "Entity",
                "Class"
            ],
            "short_form": "GO_0004190",
            "label": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)"
        }
    ],
    "relationships": [],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [],
    "def_pubs": [
        {
            "core": {
                "symbol": "",
                "iri": "http://flybase.org/reports/Unattributed",
                "types": [
                    "Entity",
                    "Individual",
                    "pub"
                ],
                "short_form": "Unattributed",
                "label": ""
            },
            "FlyBase": "",
            "PubMed": "",
            "DOI": ""
        }
    ]
}