transcription coactivator activity [GO_0003713]

A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
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Open transcription coactivator activity in VFB

VFB Term Json

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            "symbol": "",
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            "short_form": "GO_0003713",
            "label": "transcription coactivator activity"
        },
        "description": [
            "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."
        ],
        "comment": [
            "For usage guidance, see comment in GO:0003712 ; transcription coregulator activity."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
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            "short_form": "GO_0003712",
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        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
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                "short_form": "GO_0045893",
                "label": "positive regulation of DNA-templated transcription"
            }
        }
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